Except from the QuickBooks POS Store Operations Handbook:
This is where Version 10 has made great improvements. The new screen layout and payment functionality will help you to speed sales. To get to the sales screen, click on Make a Sale from the home screen. You can also click on the Point of Sale menu and choose New Sales Receipt. Once you are in the sales receipt screen it is a simple matter to scan the label that you created when you received the item. If the label has fallen off, you can type anything about the item that you know.
Clearly it is better to scan the item’s bar code into the system. It will be faster and more accurate than trying to find something manually, but it is nice to know that there are different look up methods if needed.